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IL4I1 is an immunosuppressive enzyme highly expressed in all cancers by infiltrating macrophages and in some cases, such as B lymphomas and mesotheliomas, by tumor cells. Its expression in the tumor bed favors immune escape. This process might result in a defective response to immunotherapy in cancers, in particular in the cases, which have failed or become resistant to anti-checkpoint treatments. We propose specific inhibitors of enzyme IL4I1 to enhance the anti-tumor immune response.
Cancer - Anti-tumor - Immunomodulation - Immunosuppressive enzyme - IL4I1 - Immunotherapy
The sensory properties of cosmetic products are crucial in the development of skincare and makeup products. The use of a panel of testers can only be done after a long period of non-toxicity tests and requires significant financial resources which in the end will give a subjective and unscientific opinion.
The project presented allows to follow in real time the effect of care products, make-up on the skin thanks to a sensor.
Ex vivo – Biosensor– Skin – Viscoelasticity - Cosmetic
Delineation of tumour areas with an imaging agent help to better define the area that needs to be removed during surgery. It can also help to preserve healthy tissue in order to limit the deleterious consequences of the surgery. There are currently portable optical imaging systems that can be used in the operating room, thus, we developped degradable optical imaging agents emitting in the tissue transparency zone and specific to tumour areas.
This new agents targeting specific inflammation markers allows to delineate primary tumours in order to resect without leaving tumour tissue that could be responsible for post-surgical recurrence and to highlight the functional healthy liver, so that liver metastases are negatively contrasted and too much healthy tissue is not resected.
EU & US Patent Application pending
Imaging agent - Tumours targeting - Tumours surgery - Liver metastases - Diagnostic - Near and far infra-red
While modeling and simulation are powerful and economical means of investigation, characterizing mass and / or heat transfers in turbulent and heterogeneous fluid media (gas, liquid, solid particles) poses many challenges. This is what FUGU, this software library takes up. The digital methodologies used are based on fictitious and penalization methods for the representation of various constraints, turbulence, deformable interfaces and point particles.
Ability to solve in a single simulation all the physical quantities of single- or multi-phase flows under non isothermal conditions and turbulent régime, in a coupled manner and at all scales.
Filing on 11/22/2017 with APP, n° IDDN.FR.001.480009.000.S.P.2017.000.10000
Fluid mechanic – Heat transfer – Multi-scale simulation - Multi-phase flow – Turbulent flow
The development of communication protocols between mobile connected objects ( like vehicles) and the establishment of 5G have enabled the emergence of several applications such as the connected and autonomous car. Several communicating cars can form a so-called vehicular network where communication is not limited solely to exchanges between cars (V2V) but can also be established with infrastructure (V2I), or even pedestrians (V2P). However, in the connected vehicle industry, communication capacity between vehicles and storage capacity are limited. In addition, the traffic load in this type of network is heavy. BadZak technology respond to these limitations. BadZak scans available networks and terminals On-the-fly in order to provide the fastest, most reliable and resource-efficient connection.
International Patent Application, WO2019/110594, December 2018
Internet of Mobiles Things - V2X communication - Virtual backbone - Fog Computing - SDN : Software Defined Network - VANET
The invention is an instrument measuring the concentration of fine particles in the air. It consists of an aerodynamic stage screening device directing aerosol particles according to their mass to microbalances. The choice of this instrumentation is in accordance with the standard procedures used in the field of aerosol measurement to evaluate indoor air quality. The desire to target aerosols of biological origin such as microfungi is linked to health issues, as these microbes cause allergies. Real-time and continuous monitoring of the presence of particulate matter in the air will allow more accurate analysis of outdoor and indoor air quality.
Air quality - Sensors - Microsystems - MEMS - Microbalance - Micro impactors - Micro/nano structuration - Particle pollution analysis - Mass measurement - Aerosol
Chromatographs are usually bulky and expensive equipments, while micro air quality analyzers usually provide unprecise or biased measurements. Our micro-chromatograph is designed to discriminate a whole range of different gazes with low detection levels, thanks to cutting-edge silicium-based hardware and smart signal processing algorithms. The signal- noise ratio can optionnally be increased using stochastic injection.
The whole system including pumps and electrovalves is the size of a smartphone, but the core of the silicium-based system is as small as a coin. Furthermore, the system can be tuned to analyze multiple gazes from different rooms or different environments, such as outdoor and indoor air, in a simultaneous manner.
US patent application US20150204825
Indoor air quality - Outdoor air quality - Hazardous gazes Volatile organic compound (VOC) - Chromatograph - MEMS
The invention presents a direct growth method of ZnO nanowires on civil engineering elements intended for photocatalysis for water and/or air depollution. Due to their high surface-to-volume ratio, ZnO nanowires showed excellent efficiency in the decomposition of tested dyes (AR14, MB, and MO) into less harmful products such as CO₂ , H₂O, NO³⁻, or SO₄²⁻ via a photocatalytic-induced mineralization process.
The civil engineering element coated with ZnO nanowires on its rough surface produced with this method can be integrated for instance in the development of the 5th-generation (5G) road, public garden, or in new buildings/houses. Smartly designed with new and possibly bio-based materials, 5th generation plans to make smarter roads in the near future will integrate numerous technologies including an environment depollution function. The photocatalysis process is a promising emerging solution for this aim, as it is a cheap and fast solution to degrade toxic organic compounds into harmless products. With the present invention, the photocatalysis process can be incorporated into our everyday life. Thus, incorporating metal oxide semiconductors (photocatalysts) onto civil engineering materials is a smart way to achieve this goal, as they are known to perform photocatalysis under ultraviolet lighting, or even under visible lighting with doped photocatalysts.
International patent application PCT/ EP2019/078465
Photocatalysis - Environment - Air pollution control - Water purification - Semi-conductor - ZnO - Hydrothermal method - Iron doping
New heat exchanger based on low cost material, easy to install and maintain. It is based on a flexible polymer tructure and left free in a moving external fluid.
Analyzing and reproducing natural language requires an understanding of the meaning of the sentence. To meet this need, the corpus made up of more than 20,000 richly annotated sentences in French constitutes a lexical and syntactic resource of reference for linguists and computer scientists, in particular in the case of use in automatic natural language processing.
Corpus filing on 01/28/2018 with APP, n°IDDN FR 001 050008 000 D C 2008 000 10300
Lexical ressources - Syntatic ressources - NLP
Dyslexia is a specific learning disability that affects about 7% of the population and in particular 200 000 children between ages 6 and 11 in France.
Children with specific language impairment (SLI) have difficulties in several aspects of language, including phonology, morphology and syntax, despite normal intelligence, adequate hearing, normal learning opportunities and the absence of any neurological or psychiatric trouble.
RapDys are gamelike exercises based on carefully chosen and tested voicing continua. They can be done under the supervision of a speech and language therapist and further on at home.
Dyslexia - Specific language impairment (SLI) - Phonology - Speech Perception
HYCOs is a new class of anti-inflammatory agents with a dual biological activity (Nrf2 activators and CO-releasing molecule) with applications in inflammatory diseases such as multiple sclerosis, psoriasis and also wounds cicatrization.
Every type of molecule has a distinct «Raman signature» that can be enhanced by special surfaces called SERS substrates, standing for “Surface Enhanced Raman Spectroscopy”. SERS techniques are useful to detect molecules at very small concentrations (pico or femtomoles per litre). The SERS substrate can either be generic or designed for special applications, such as trace detection of explosives, drugs or pollutants.
Common techniques to produce SERS substrates involve lithography processes, and are thus rather costly. On top of that, measures lack of reproducibility. Our invention is based on a bottom-up colloidal synthesis, as the substrate results of the self-organization of metallic nanorods. Measures are more reproducible and reliable than most commercial substrates with far less variability, hence allowing a better ability to discriminate and to detect traces (see picture).
Patent WO2018069646
Raman spectroscopy - Self-organization of nanoparticules - Trace detection - SERS : surface enhanced Raman spectroscopy
This non-Bayesian statistical algorithm is used for detecting anomalous values (or series) in longitudinal biological follow-ups. This method is practical, easy to implement and efficient as soon as 3 independent measures are gathered. It integrates periodicity and seasonality and allows to detect abnormal values (or series) in multiple correlated biomarkers.
The main interest of the method, is that it is only computes the appropriate indicators in a series of observations from one individual. Moreover, a single procedure is performed for the whole series, thus avoiding cumulated errors commonly involved in multitests. These intra-individual comparisons allow defining very tight / personalized abnormality thresholds without the need to use a priori samples for determining said thresholds (risk of poor representativeness). The method shall be used for the longitudinal assessment of physiological or biological markers during clinical trials or medical follow-up of patients or athletes in the context of medical control for humans or animals. A first study has been initiated on a cohort of more than 2200 professional football players for a 3 years campaign involving the assessment of 5 biological parameters.
European Patent Application EP17306583
Statistical algorithm - Longitudinal assessment - Biomarkers - Anomalous value detection - Anti-doping - Intra-individual thresholds
Existing techniques for measuring electrical conductivity of hydrophilic films, as ion exchange membranes (IEM), either work with solutions at low concentrations, or provide hard-to-reproduce measures, or require to take the membrane out of its equilibrating solution, thus inducing a bias in the measurement.
Our technology is a clamp with two articulated arms that characterizes the IEM with no bias in measurement thanks to a contactless technology enabling on-site measurement with no contact resistance induced. It is compatible with a wide range of concentrations of equilibrating solutions (from 0.01 M to 1 M) and is compatible for membranes or hydrophilic films with a thickness between 50µm and 1 millimeter, making on-site measures convenient and reliable. Measure precision is 1% for solutions with a concentration inferior to 0.1 M and 3% for 1 M concentrations.
Priority patent application
Clamp - Electrical conductivity - Ion-exchange membranes (IEM) - Hydrophilic films - NF X45-200 norm
Our device converts mechanical energy into electricity, when repeatedly pressed and released by an external mechanical action. The device has a sandwich structure, with flexible or solid electrodes on the surface and with an organic electret material core (see picture). It can be embedded into an object, a cloth or be used as a “second skin”.
Electric charges trapped within the device induce an electric current through a charge when a mechanical deformation is applied. The device has no resonance frequency and thus works at any mechanical frequency. Besides, the organic material is designed in such a way so that electric charges remain stable over time, leading to long standing performances. With a finger tapping activation, the first 3cmx3cm prototype reaches a peak voltage of 27 V and a power of 45.6 μW. Performances can be further largely enhanced by optimizing triboelectric effect, increasing the size of the device and/ or by using it under different conditions (higher mechanical frequencies, more pressure).
Powering/improving battery lifetime for :
Pending patent
Mechanical (kinetic) energy harvester - (Tribo)electret material - Triboelectricity - Electrostatic transducer
III-V semiconductors are a category of materials useful for optoelectronics applications, thanks to the physical properties of their crystalline structures. AlGaAs is one of them and has superior performances over silicon such as:
The AlGaAs-on-Insulator plateform, which exhibits higher performances than SOI, was achieved thanks to a monolithic construction combining a high-contrast refractive-index ratio between the insulating layer and the AlGaAs waveguide. Our invention deals with the monolithic fabrication of a thick layer of AlOx (>1μm), which plays the role of optical substrate and enhances the light confinement inside an AlGaAs heterostructure on top of it.
Our technology can first be used to develop Surface Plasmon Resonance (SPR) sensors based on a dielectric, instead of gold or silver, thus avoiding local heat peaks that can affect the sensitivity of the sensor. As a first proof of concept, frequency doubling has been demonstrated, with a conversion efficiency up to 5 orders of magnitude higher than the established record of second harmonic generation for plasmonic nanoantennas.
Our technology could also be used to design low lasing threshold and fast modulation laser, which would lead to decrease the electric consumption of lasers used for example in datacenters.
PCT patent application WO2017/140804A1 filed in 2017
Photonics - Non linear optics - Laser - AlGaAs - Insulator - III-V semiconductors - Monolithic platform
The most advanced commercial technologies for the detection of Terahertz (THz) and far infrared electromagnetic waves have major drawbacks : bolometers work at very low temperatures (4 Kelvin), while Golay cells are notoriously slow (20 Hz). Furthermore, those detectors are bulky, with a typical volume of the device in the 10cm x 10cm x 10cm range.
Our MEMS device has a volume in the mm3 range and has a very quick response time (MHz). It works at ambient temperatures. It is possible to tune precisely the resonance frequency of the sensor at production time.
Patent application
THz - Far-infrared - Bolometer - Golay cell - Noise Equivalent Power (NEP)
State-of-the-art nanofabrication tools (electronic beam lithography, reactive ion etching) can nowadays reach a few nanometer precision. This is still not accurate enough in optical applications such as metrology where collective behavior of resonators is targeted.
Our method reaches picometer precision (3 orders of magnitude better than state-of-the-art). The method consists in shedding light on resonators, so that a light-activated chemical etching process can take place. When using the proper wavelength, light intensity is locally amplified by the resonator. The result is that the resonator is gently etched while its nearby environment remains intact. This technique allows as well collective tuning of several resonators for spectral alignment.
Patent application
Nanophotonics - Optical resonators - Silicon photonics - High precision spectral tuning - Photoelectrochemical etching
Colorectal cancer is the second most lethal cancer type in developed countries and more than 70% of the polyps, when present in one’s colon or rectum, can eventually change into tumor cells (mostly adenomas).
Polyp’s visual detection during colonoscopy is the world’s gold standard in colorectal cancer diagnosis. However, today polyps detection rates during these preliminary visual inspections commonly fall below 80%, resulting in that almost 50% of diagnosed colorectal cancer were not detected during a first colonoscopy, and it is widely assumed that these results are significantly practicioner-dependant. Still, all existing solutions focus on contrast modification or vision angle widening for best inspection of the mucosa.
Our software aims at significantly enhancing polyp’s detection rate by visually alerting the practitioner in real time during a colonoscopy procedure. The method is based on optimized reinforced active-learning algorithms for image to image analysis. It is adapted to real time video treatment (more than 25 fps analyzed) and aims at detection rates higher than 90% at the practitioner level.
International patent application PCT/ EP2017/064972. Filed on June 19, 2017
Computer Aided Detection (CAD) - Polyps - Cancerology - Colonoscopy - Endoscopy - Video analysis
