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Cystic fibrosis is the most common inherited genetic disease in the Caucasian population (1/4500). Respiratory involvement is one of the main causes of death. Patients are monitored using clinical and functional markers and chest scans. But these follow-ups take a long time and are too variable. The method developed allows automatic scoring of pulmonary involvement in cystic fibrosis by CT scan. This score is well correlated with respiratory function, which was verified in two independent cohorts of patients.
CT quantification - Automatic scoring - Cystic fibrosis Lung segmentation - Histogram analysis
New optimization algorithm based on fractal decomposition. Thanks to a new approach of covering space this algorithm can solve problems with a large number of variables while providing an exact answer. All this with a very low complexity (logarithmic).
Viologen derivatives have the ability to change color in UV-Vis range as well as to strongly absorb in near-IR. Their redox properties can also be used for electrochemical energy storage.
Based on these multifunctional materials, we are developing a dual system with electrochromic properties to adjust the optical contrast as well as the ability to store energy, resulting in an electrochromic energy storage system. Unlike commercial systems, transparent mode is here achieved without current, significantly reducing system power consumption. The organic layers can be deposited either on rigid glass or on flexible plastics. Finally, this system is being developed using bio-based products.
EP3453038 / US20190173078
Electrochromic - Optical contrast - Energy storage - Battery - Smart glass - Electroactive ionic liquid polymers
There are a multitude of methods for producing magnetic nanoparticles with a given magnetic behavior (paramagnetic, ferromagnetic, etc.) and a given magnetic category (soft, semi-hard, hard). But for the same composition of precursors and a given process, there is still no simple and effective way to modulate the magnetic category. Based on coprecipitation of precursors and a hydrothermal and/or solvothermal synthesis, this innovative production process allows to easily choose the magnetic category (soft, semi-hard, hard) of the nanocomposites while using the same composition of precursors.
Patented technology
Nanoparticles - Ferrites - Solvothermal - Hydrothermal - Magnetic
Following acute stresses like chemotherapy or radiation, the hematopoietic system quickly adapts by a process termed “emergency” or “stress” hematopoiesis. In erythroid progenitors, the researchers recently identified a functional cellautonomous serotonergic network with pro-survival and proliferative functions (Cell Reports 2019). Pharmacologic restoration of serotonin levels using selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, a common antidepressant, can rescue the anemic phenotype in mice models. In this project, the team has shown that the serotonergic system could be a valuable therapeutic target in radiation or chemotherapy-induced cytopenia, alone and in cooperation with known hematopoietic growth factors, such as G-CSF. Particularly, fluoxetine alone or in combination with G-CSF showed an additive effect on the recovery of the three myeloid lineages and on overall survival of mice following sub-lethal irradiation. This new combination of drugs offers interesting avenues to fasten hematopoietic recovery of cytopenia thereby decreasing the risk of complications for patients during aplasia.
Patent application WO 2020/109520 ; EP, US, CA
Cytopenia - Serotonergic system - Hematopoiesis - Aplasia - Serotonin reuptake inhibitors (SSRI) - Bone marrow failure
Approximately 25% of primary human breast cancers are due to deregulated ErbB2/HER2 expression. Therapies targeting HER2 have improved patient survival, but de novo and acquired resistance remain a challenge, with only 25% of treated patients responding to current therapies. The researchers identified several miRNAs in the miR-200 family that are upregulated in HER2+ breast cancer cells and tumor samples and whose high expression levels are associated with worse prognosis in HER2+ breast cancer patients. They designed, optimized and validated a novel biotherapeutic ASO molecule for the inactivation of miRNA-429 for the treatment of cancers with HER2 abnormalities, including HER2+ breast, gastric and ovarian cancers.
Therapeutic efficacy on HER2+ breast, gastric and ovarian cancer cells, including tumors that are resistant to the current therapeutic arsenal.
WO 2019/081607; US, JP, EP
HER2+ cancers - Breast, gastric, ovarian cancers - Targeted Biotherapies - MiRNA - Personalized medicine - Antisense oligonucleotides
All existing Wavefront sensors (WFS) can only measure several wavefronts by sequential image acquisition. Sequential multi-spectral WFS has several drawbacks: it is difficult to implement, expensive, and incompatible with single-pulse laser characterization. This innovative system now allows simultaneous wavefront shapes measurement at different wavelengths using the multi-spectral (broadband or multi-line) light beam. It relies on the recent development of a wavefront analyzer (DiPSI) based on the use of a simple diffuser that obviates all these drawbacks by performing spectral measurements simultaneously. This aspect is advantageous for a variety of applications such as optical metrology, laser metrology, quantitative phase imaging and ophthalmology.
Patent application filled in March 2019
Multi-spectral wavefront analyzer - Wavefront sensor (WFS) - Spatio-temporal wavefront analyzer - DiPSI - Quantitative Phase Imaging (QPI) - Ultra-short pulse laser
The development of efficient water filtration systems is an important challenge for environmental engineering. Activated carbon is widely used for adsorption of organic pollutants. However, it is only a separation process and current regeneration processes all present some important drawbacks. A new electrochemical process for in situ regeneration of activated carbon fibers has been developed. Activated carbon fibers allow for fast adsorption of organic pollutants and are subsequently used as cathode during the regeneration process. The objective is to recover the adsorption capacity of the initial material and to degrade organic pollutants.
Patent ref. Number PCT : PCT/EP2019/055803
Water treatment - Activated carbon regeneration - Electro-Fenton - Oxidation of organic pollutants - Activated carbon fiber - Degradation and mineralization of organic pollutants
This so called « Gene-directed enzyme prodrug therapy (GDEPT) » consists in bringing an optimized gene - allowing to convert cyclophosphamide (CPA) into toxic metabolites 13 times more than native conversion - into the tumors, thanks to an efficient vector, mesenchymal stem cells (MSCs), and a specific (intra-arterial) administration. There, it eradicates the tumor and triggers a specific immune response, resulting in a vaccinating effect. POC in vivo have been established either in mice (treatment and rechallenge experiments), but also in an orthotopic model of hepatocarcinoma (VX2) in rabbits. Those last experiments confirmed breakthrough results, compared to Gold Standard (chemoembolization), either in terms of tumor & metastasis drastic reduction but also remission levels...
Gene-directed enzyme prodrug therapy - Cyclophosphamide highly active metabolite conversion - New cancer treatment - Gene & cell therapy
Homomorphic cryptography makes it possible to host encrypted documents in the Cloud, while offering queries on their content, without exposing secret data. However, many Internet applications of document computing require processing massive streams of XML data, which poses real technological challenges for the efficiency of processing techniques and data security. CSQM, the completely new model proposed, is a flow processing approach which makes it possible to minimize the consumption of resources (time, memory) for a given request on a document of any size.
Deposit of the software at the APP under number IDDN.FR.001.150002.D. P.2012.000.20800
Queryable encryption - Structured encryption - Confidential cyphered Stream-Querying Model (CSQM) - XML data and XPath queries
PCM improve thermal performances of materials by delaying temperature increase and decrease and by mitigating the temperature peaks. Most PCM available are based on state change implying solid and liquid transitions which present major issues such as leakage risks and volume variations.
Our technology is based on a solid-solid phase change material that avoids any of these issues. The temperature of phase change can be tuned between 20°C to 65°C according to the application. The PCM presents a Shore hardness which allows its grinding up to grain size lower than 50 μm. The grain size of the PCM can be controlled by sieving for injection in different matrixes (plaster, plastics...). The environmental impact of the PCM is limited, as the synthesis process does not involve any solvent or catalyst.
Patent application WO2017198933A1
Solid-solid Phase Change Material - Thermal energy storage - Phase shift - Energy efficiency - Thermal comfort - Sustainable building
Nanotopo is a new nanocrystal formulation improving etoposide biodisponibility in cancer treatments.
New high resolution imaging software of fine tissue vasculature without injection and based only on a video of the blood vessels.
PTL Dx is a panel of new biomarkers of the cervicovaginal secretions predicting spontaneous preterm birth in a 24h window.
Diffuse Large B-cell Lymphoma (DLBCL) is the most common lymphoma in adults. Even though cure rates have significantly improved in the last few years since the introduction of new immunochemotherapy treatments, refractory/ relapse cases reach up to 40%. DLBCL is a highly heterogeneous disease and new biomarkers are highly awaited for better DLBCL stratification, prognosis and tailored therapies. We have shown that the transcription factor RelB is frequently activated in a large cohort of DLBCL patients and cell lines independently of their known subtypes, and that RelB activity defines a new subset of DLBCL patients with a peculiar gene expression profile and mutational pattern. Additionally, the newly defined RelB-positive subgroup exhibits a dismal outcome following immunochemotherapy. This new RelB signature then contributes to better DLBCL patient’s stratification and prognosis and paves the way toward new therapeutic approaches based on RelB activation status.
Priority Patent Application filed in 06/2020
Diffuse large B-cell lymphoma (DLBCL) - RelB - NF-ĸB signaling - Prognosis - Biomarker - Patient stratification - Transcription factor
Diffuse Large B-cell Lymphoma (DLBCL) is the most common lymphoma in adults. Even though cure rates have significantly improved in the last few years since the introduction of new immunochemotherapy treatments, refractory/ relapse cases can reach up to 40%. New clinical management and therapeutic options are therefore necessary for DLBCL patients. We used a combination of L-asparaginase and Metformin for a combined anti-metabolic treatment targeting both the OxPhos and glycolytic energy metabolism of DLBCL cells. We have demonstrated that combining these two drugs strongly induces apoptosis not only in OxPhos, but also in Glycolytic DLBCL cells. Most importantly, the clinical proof of concept of the efficacy of a new protocol based on both drugs administration was established in a human refractory/relapsed DLBCL patient with induced apoptosis after only 24 hours of treatment and very promising reduction of tumor volume and partial remission. These results pave the way toward new therapeutic approaches for refractory/relapsed DLBCL patients.
Priority Patent Application filed in April 2020 (EP20315147.7)
Diffuse large B-cell lymphoma (DLBCL) - Refractory/relapsed DLBCL patients - L-asparaginase - Metformin - Energy metabolism - Mitochondrial apoptosis
Blood malignancy such as chronic myeloid leukemia (CML) and lymphomas are pathologies dealing with a high relapse rate. Allogeneic hematopoietic stem cell transplantation (Allo-HCT) and Donor lymphocyte injections (DLI) are among potential strategies to treat or prevent relapse, however, response rate generally remains low. Treg cells play a key role in the fine tuning of the immune responses in alloHCT. Cell therapy using Treg infusions to prevent graft-versus-host disease (GVHD) showed very promising results in the clinic. Conversely, ex vivo Treg depletion from DLI has been shown to enhance the graft-versus-leukemia (GVL) effect in patients who relapsed after alloHCT without previously developing GVHD. Using an anti-TNFR2 mAb, the team provided proof of concept that an anti-TNFR2 treatment can mediate a potent GVL/GVT effect in different experimental models of hematological malignancy relapse after alloSCT through inhibition of Treg population. These results pave the way toward a novel immune checkpoint therapy to modulate alloreactivity after allo-HCT through the TNF/TNFR2 signaling pathway and, more widely, open new perspectives to amplify antitumor responses in solid cancers by directly targeting Tregs and tumor cells through their TNFR2 expression.
WO2017220711A1
Graft versus Leukemia (GvL) - TNFR2 Monoclonal antibody - Donor lymphocytes infusion (DLI) - Treg lymphocytes - Alloreactivity
Automated (unsupervised) detection of subsequence anomalies in time series. It can be determine the health of a system, equiped with sensors, by detecting and graphically represent subsequence anomalies in a time serie, without prior knowledge of the system.
Customized and personalized indoor guidance and localization of crowds or individuals, inside a building, for either evacuation or sheltering (during emergency situation) or the best routes to reach spots of interest (Indoor locationbased services, for example, shop with special offers in commercial malls) is of utmost importance for safety issues or customer satisfaction. Most of the existing evacuation systems are mainly based on warning mechanisms (sound, visual, ...), and pre-established routes which do not consider the presence of obstacles or spots of interest popping out, dynamically, in real-time. The existing solutions are not always able to provide simple and effective evacuation/ guidance instructions. Thanks to progress in telecommunication technologies, connected things and BIM (Building Information Model), the GuidEvac solutions provide people or evacuation agents, in indoor context inside buildings, with the best evacuation/guidance instructions in real time.
Patent application EP19306270 filed on October 2, 2019
Indoor location-based services - User-oriented guidance - BIM - Safety of persons and assets in buildings - Emergency evacuation - Optimal queuing and routes - Connected things (IoT) - Zone of interest
This invention results from the combination of micro-organic electronic (OLED) and microwave electronics. It drastically enhances the electrical time response of OLED. As a result, OLEDs can sustain 1ns electrical pulse excitation with highcurrent density and deliver intense light emission (4.0 106 Cd/m2). High-speed organic optoelectronic combine the fast response of optoelectronics and the simplicity of fabrication, which opens numerous applications:
Patent application
Organic electronics - Micro-electronics - Opto-electronics - Micro OLED - Display - Optical transmission
